First listed on: 15 May 2018

CSIRO Postdoctoral Fellowship - DNA methylation diagnostics for disease

• Are you passionate about the application of epigenetics in human health?

• Undertake critical research to aid in the development of diagnostics for diabetes

• Make a difference at CSIRO - Australian science, Australia’s future!

The position:

CSIRO Postdoctoral Fellowships help facilitate the recruitment and development of our potential leaders.  They provide valuable opportunities for scientists and engineers to launch their careers, extend professional networks and enhance their career prospects.

As a Postdoctoral Fellow with CSIRO Health and Biosecurity, you will undertake research utilising a large database of Whole Genome Bisulphite Sequencing data to identify new DNA methylation based biomarkers for the detection and stratification of metabolic disease. Your research will focus on the development of a novel clinical assay for the early detection of diabetes. Blood based biomarkers (also known as “Liquid Biopsy”) for disease is a rapidly developing field and this project will make use of the latest technological developments in this space (e.g. digital PCR). You will ideally have expertise in epigenomics/genomics and bioinformatics with a strong background in molecular biology. As part of the CSIRO postdoctoral development program, we will provide you with formal support to expand your bioinformatics skillset.

Specifically you will:

• Develop innovative concepts, theories, tools and techniques related to the analysis and integration of epigenomic data.

• Develop DNA methylation assays and test these on clinical plasma samples.

• Participate in collaborative research and liaise with external collaborators.

• Develop innovative decision frameworks with impact in clinical and biotechnological applications.

• Undertake regular reviews of relevant literature and patents.

• Produce high quality scientific and technical outputs suitable for publication in journals and for conference and stakeholder presentations.

You will join the multi-disciplinary, award winning Epigenetics Team with a track record in developing epigenetic biomarkers of disease. The team has a long history in DNA methylation biomarker development which includes the co-development of Colvera(tm) with the Clinical Genomics company. Colvera(tm) is a blood-based diagnostic for monitoring the recurrence of colorectal cancer. The development team was recently awarded the prestigious Eureka Prize for Innovation in Medical Research.

Location:      Sydney, New South Wales, Australia
Salary:          AU $83k to AU $91k per annum, plus up to 15.4% superannuation
Tenure:         Specified Term of 3 years (or part time equivalent)
Job ref:         56942

As a minimum requirement, you will hold a doctorate (or will shortly satisfy the requirements of a PhD) in a relevant discipline area such as molecular biology, (epi)genetics or bioinformatics. You will also have:

• High-level communication and team skills, including a record of publications in quality journals and a history of professional behaviours.

• Knowledge and understanding of molecular biology (including lab experience).

• Experience in bioinformatics for the analysis and interpretation of genomics datasets.

• Familiarity with epigenetics principles.

• Proficiency in data analysis using R, Python/Numpy or MATLAB.

• A record of science innovation and creativity

To see all the criteria required for success in this role, click on the ‘Position Details’ link below. Apply today!

Position Details

To be eligible for this postdoctoral fellowship, you must have less than 3 years of relevant research experience since gaining your PhD.


We imagine. We collaborate. We innovate. At CSIRO, we do the extraordinary every day. We innovate for tomorrow and help improve today – for our customers, all Australians and the world. We do this by using science and technology to solve real issues. Diversity is the compass that navigates our innovation. We provide an inclusive workplace that respects, values and actively pursues the benefits of a diverse workforce - CSIRO

We work flexibly at CSIRO, offering a range of options for how, when and where you work. Talk to us about how this role could be flexible for you.  Find out more Balance

How to apply: Please load one document containing your CV and a brief cover letter which outlines your interest in the role and your motivations for applying (Maximum 2MB). At the end of the online application process, you will also be required to respond to some screening questions. 

Applications close: Tuesday, 19 June 2018 (11:59pm AEST, Australian Eastern Standard Time)

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